A recent study suggests that people who discontinue popular slimming jabs like semaglutide or tirzepatide tend to recover reduced body mass at a significantly accelerated pace than those who end conventional diet and exercise regimens.
Published data in a prominent medical journal shows that while overweight individuals can lose about a fifth of their body weight while on the medication, the weight is regained at an average rate of 0.8 kg per month upon discontinuation.
"People purchasing these drugs should be informed of the potential of quick weight regain when the medication ends," warns expert Dr. Susan Jebb.
This pace of regain implies a reversion to original weight within about 18 months.
Comparing Therapies
The analysis, which reviewed 37 of studies involving over 9,000 of patients, compared the effects of these new drugs with other pills.
Researchers point out that people who shed pounds through diet and exercise typically see a more gradual weight regain—approximately 100 grams monthly—once they finish.
Understanding the Fast Regain
Doctors believe the mechanism of the injections accounts for the amplified weight return.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing GLP-1 levels far above than the body's typical production may cause the body to generate a reduced amount of its endogenous hormone, and could diminish sensitivity to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this hormone supplement means appetite is unsuppressed, making binge eating a significant risk."
A Chronic Issue?
The NHS recommend the injections for individuals with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts contend that, considering the significant potential of relapse, the therapy should be considered ongoing.
This view is reinforced by drug manufacturers, who say that the findings "emphasize the long-term character of excess weight," comparing it to managing diseases like high blood pressure.
Patient Experiences
People who have come off the jabs explain a intense resurgence of appetite.
"I experienced a trigger that goes on and you become ravenous," said one woman.
This challenge is compounded if users have not developed sustainable lifestyle or habit changes during treatment.
Widespread Adoption
Recent estimates suggest that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand being substantial.
- Use is more common among females than men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than the NHS.
Finally, experts emphasize that while the jabs are potent agents for shedding pounds, they are not a magic fix and maintained weight loss likely depends on integrated lifestyle changes.
